Abstracts of Selected Articles
(The following abstract from the June 1964 issue of BIRTH DEFECTS is reprinted with the permission of the National Foundation - March of Dimes.)
EMBRYOPATHIES INDUCED IN MAMMALS.
(In French) Therapie 19(l):43-l64, Jan.-Feb. 1964.
Fave, A. (Pfizer-Clin. Labs., Paris, France.)
A catalogue of known agents teratogenic for various species is tabulated from the literature. Brief discussions of the history of experimental teratogeny, types of pathogenic results in embryos, determining factors in pathogenic activity, and a review of pharmacological nomenclature and embryological terminology are included. (12l2 references)
(The following abstract is reprinted from the April 1965 issue of THE BULLETIN of the DOW CORNING CENTER for AID TO MEDICAL RESEARCH issued quarterly at Midland, Michigan.)
ARTIFICIAL TENDONS: EARLY DEVELOPMENT AND APPLICATION
James Hunter. Amer. J. Surg. 109:325, 1965
A number of types of artificial tendon prostheses have been developed by extruding Silastic (R)* silicone rubber over polyester fibers or ribbons. These have been designed to be implanted in flexor or opponens positions and can run to the palm or up into the forearm. They act as movable prostheses around which new tendon sheaths develop, and are used in badly damaged tendon beds where conventional grafts would be likely to fail.
After suturing the artificial graft into place, hands are immobilized for a month, after which active motion and stretching exercises are begun. Maximal range of motion should develop in 3 or h months. At any time after this, the prosthesis may be replaced by suturing a live tendon graft or transfer to one end of the prosthesis and pulling it through the untraumatized new tunnel. Live grafting may be done after k weeks but it is better to wait as benefits accrue during the period of active function.
A total of l8 implants has been placed in the hand and 11 in the forearm. Because of good functioning of the prostheses, 11 have been allowed to remain implanted, the longest for 34 months. In 11 other patients they have been replaced by live tendons, all of which have had complete acceptance with the new sheath.
The new tissue bed begins to organize almost immediately on the surface and within a few days a discrete delicate mesothelium-like membrane is formed. Clear serous droplets similar to synovial fluid form on the surfaoe.
Results show that this artificial tendon functions successfully as a temporary replacement, forming an excellent gliding canal which permits motion. This makes it possible to bring about tendon motion through scar tissue.
*Silastic 372 medical grade elastomer.
From the Jefferson Medical College, Philadelphia.