The following abstract is reprinted with permission from the September 1966 issue of Birth Defects, The National Foundation-March of Dimes.
Congenital Heart Defects With Developmental Anomalies Of The Digits. (In Hungarian) Orv. Hetil. 107(24): 1126-1129, June 12, 1966.
Fono, R. (Und Pediat. Clin., Med. Univ. Budapest, Hungary.)
In a two-month-old female infant with ventricular septal defect, the third phalanx of the fifth finger of the left hand was missing, and X-rays showed constriction of the soft parts between the second phalanx and fingertip; the little finger was short and lacked the nail.
In a ten-year-old girl with atrial and ventricular septal defect, the terminal phalanges of the fifth fingers of both hands were missing; both little fingers were very short and lacked nails. The terminal phalanges of the second and third fingers of the right hand and of the second finger of the left hand were thinner and shorter than the rest.
In a 7-3/4-year-old boy with pentalogy (sic) of Fallot, the second phalanx of the fifth toe of the right foot was rudimentary and the third phalanx missing; in the left foot, the first phalanx of the fifth toe was shorter than that of the corresponding right toe, and the second and third phalanges were missing. The third phalanx of the fifth finger of the left hand was somewhat shorter than in the right hand. The boy's mother also exhibited brachydactylia. (No evidence of familial predisposition could be found in the other two.) In all three, heart and digital defects alike were attributed to a metabolic error, occurring in the fifth to sixth week of embryonal life and inhibiting the development of some part of the mesenchyma. (8 references. )